The epinephrine infusion study is another type of provocative
study and an aid in the diagnosis of long QT syndrome. Although
not one of the major or minor criteria, certain rhythm distur-
bances such as simple ventricular ectopy can be determined to
arise from excess adrenaline influence and thereby justify the
use of beta-blocker therapy in the treatment of the arrhythmia.
The test consists of stepwise increments in the infusion of
epinephrine (adrenalin) in five-minute intervals. At the end of
each stage, a 12-lead electrocardiogram and vital signs are
obtained, similar to data collection during an exercise stress
test. Abnormalities of rhythm including the production of atrial
or ventricular premature beats are a common endpoint. Sedation
is not necessary. Also, the electrocardiogram is analyzed for any
unique changes in the ST segments or T waves. Standardization
of the technique has not been established, however.
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diagnostic tests.
